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Study the effects of certain precautions on serum & ammonia levels.

To determine the etiology and clinical presentation of increased serum ammonia in infants and children presented to the Pediatric Genetic unit, Assiut University Hospital

-To study the effects of certain precautions on serum ammonia levels.

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Detailed Description

  1. hyperammonaemia is often considered a metabolic derangement due to inborn errors of metabolism Such aHyperammonaemia is defined as levels >110 µmol/L (198 µg/dL) in the neonatal period (including preterm) and >50 µmol/L (90 µg/dL) from that age onwards, The predominant clinical signs of acute hyperammonaemia are mostly due to cerebral oedema, They include irritability, rejection of feeds, vomiting or drowsiness in neonates and infants. In children, adolescents and adults, the main clinical signs are associated with differing degrees of acute encephalopathy: altered consciousness, ataxia, seizures, and coma Persistent or intermittent hyperammonaemia can produce chronic symptoms such as psychomotor delay or growth retardation. Older individuals can exhibit eating disorders or a wide spectrum of neuropsychiatric symptoms. In children, s organic acidemia, systemic carnitine deficiency, Reye syndrome, toxins, drug effect, or liver disease. On the other hand, if there is normal lactate and no metabolic acidosis associated with the hyperammonemia, then UCD, dibasic aminoaciduria, or transient hyperammonemia of the newborn are more likely. The association of elevated liver enzymes with hyperammonemia is most consistent after insult from hepatotoxins, Reye syndrome, or carnitine deficiency.
    1. The severity of the clinical presentation depends on the peak ammonia level but is also influenced by the age of the patient, speed of onset or the presence of other underlying conditions. In many cases there is a triggering factor such as protein catabolism caused by prolonged fasting, fever, infections , gastrointestinal bleeding, dehydration, high protein intake, anesthesia, and surgery or use of specific medications. Ammonia level de.

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Age icon
Age
18 - None
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Gender
All
NCT ID icon
NCT ID
NCT13295
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Phase
0
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Status
Recruiting Now
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Medical Condition
acne

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Medical Condition
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The Study
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About Clinical Trials
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Your Journey

01
Receiving the medication
You would receive etanercept (Enbrel) twice a week for 12 weeks and then once a week for 12 weeks. Etanercept, as well as study related medical care, is provided at no cost.
02
Visiting the study site
Study participation involves approximately 8 visits to your local study center over 6 to 7 months.
03
Follow-up
There would also be a follow-up telephone call 30days after completing the study. No visits are required after participation is complete.

Call 1800-9860-568 now to find out if you are eligible.